A member asked:

Can lamictal and prozac (fluoxetine) be taken together for bipolar 2? if so in what doses? talked to my dr about it today. my friend is taking this combination.

3 doctors weighed in across 2 answers

Risky combination: Lamictal increases Prozac's toxicity, with subsequent risk for seizures, arrhythmia, rhabdomyolysis (muscle tissue breakdown), severe bleeding disorder, acute renal failure, respiratory failure, and the potentially lethal serotonin syndrome. Such a drug combination must be used with caution and monitored closely by a specialist.

Answered 6/26/2014

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Dr. Stephen Southard answered

Specializes in Internal Medicine

A possible combo: The doses depend on your response to the medications and tolerance of any associated adverse effects. It also depends on what other medications you may be taking, particularly other mood stabilizers.

Answered 6/13/2014

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