My pdoc said that smoking causes saphris (asenapine) not to work as fully, if you take 10mgs more like taking 8 when you smoke, is this true? how could he know?

Like any drug,: tob and the chemicals in tob. products is no different; it is metabolized in our bodies by our organs (i.e: liver) and so are the medications prescribed. There are drug interactions between tob and these meds, i.e: Saphris (asenapine). Tob use will tie up necessary proteins needed to aid Saphris (asenapine) to function properly, and dosage will be adjusted accordingly in a tob user. This is common for many meds/tob use.