See answer: Testosterone (T) exists in blood in three forms: 50-60% tightly bound to Sex Hormone Binding Globulin (SHBG) protein (biologically inactive); 40-50% weakly bound to Albumin protein (active); and 3-5% unbound/Free T (active). Hyperthyroidism can cause higher levels of SHBG (inactive T) leading to higher serum levels of Total T, but unchanged or relative decrease in the two active forms of T.
Answered 6/24/2014
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