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A 28-year-old male asked:

My brother is hbe ag neg and antibody hbe ag positive. his viral load is 50000iu/ml. alt is 33. u/s noramal. ge prescribed entecavir 0.5mg.is it good?

1 doctor answer1 doctor weighed in
Dr. John Fung
General Surgery 39 years experience
Probable resistance: Entecavir is a nucleoside analog and has potent antiviral activity against hepatitis B virus (HBV) - the emergence of drug resistance is rare. If indeed his HBV viral load is 50,000 (I would repeat), then he has probably developed a mutation. The addition of adefovir may result in suppression, but only in about half of patients. Tenofovir may be warranted. See a hematologist for advice

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Last updated Jun 25, 2014

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