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A 44-year-old member asked:

how long does it take for depakote to start working?

1 doctor answer2 doctors weighed in
Dr. Jeff Jacobs
Child Psychiatry 22 years experience
1-2 weeks: On average, for the treatment of psychiatric disorders, it takes 7-14 days after achieving a therapeutic blood level. I will defer to my neurology colleagues for commenting on how long it takes to start working for seizures and/or migraines.

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A 41-year-old member asked:

Does Depakote cause increase in suicidal thoughts?

2 doctor answers6 doctors weighed in
Dr. Marianne DiNapoli
Dr. Marianne DiNapolianswered
Obstetrics and Gynecology 8 years experience
It can.: Depakote (valproic acid) is a medication that can be used to control seizures or as a mood stabilizer. It has been shown to cause a slight increase in suicidal thoughts. If you or someone you know is having suicidal thoughts, contact a physician immediately.
A 31-year-old member asked:

Do some of the effects of Depakote on fetus wear off over time?

1 doctor answer1 doctor weighed in
Dr. Nikolaos Zacharias
Maternal-Fetal Medicine 26 years experience
Avoid in pregnancy!: Depakote should be the last drug to be considered for epilepsy therapy in pregnancy because of its strong embryotoxicity and causal relationship with severe fetal anomalies (ranging from anencephaly and myelomeningocele to valproic acid embryopathy).
A 29-year-old member asked:

What are side effects from the anticonvulsant depakote?

1 doctor answer2 doctors weighed in
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 32 years experience
Side effects: Both can cause nausea & headaches. Depakote side effects are tremors, inc. Weight, leg cramps, ataxia, swelling of face, hair loss, irregular menses in females, rash. Zoloft (sertraline) side effects are restlessness & diarrhea.
A 33-year-old member asked:

What are the chances of dying from overdose of depakote?

1 doctor answer2 doctors weighed in
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 32 years experience
Depakote OD: Can cause injury to liver and nervous system and blood, depending on dose and length of time. If taking Depakote regularly, blood levels checks are vital.
A 42-year-old member asked:

How different is divalproex vs Depakote er?

1 doctor answer1 doctor weighed in
Dr. Bennett Machanic
Neurology 52 years experience
Duration: Depakote er is a branded drug which can be taken once daily. Steady drug levels are maintained, and adverse events may be lower due to lack of peaks in the blood stream. There are now generic forms of immediate release "depakote", but these must be used two or three times daily to achieve a consistent effect.

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Last updated Oct 9, 2019

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