Could you take bactrim (sulfamethoxazole and trimethoprim) ds and an antihistamine together?

Bactrim (sulfamethoxazole and trimethoprim) DS: Yes, you can take Bactrim (sulfamethoxazole and trimethoprim) DS and an antihistamine together. If you are taking it due to a reaction to the Bactrim (sulfamethoxazole and trimethoprim), then of course, you would need to stop the Bactrim (sulfamethoxazole and trimethoprim) and tell your physician. I am assuming that you are talking about taking the antihistamine for other allergy purposes, though.