A member asked:

How long does zyrtec 10mg stay in system? and how long should should i wait before taking a xanax (alprazolam)? half of 0.25mg.

3 doctors weighed in across 2 answers

8-10 hours: Zyrtec's half life is around 8-10 hours. It is supposed to be a non-sedating antihistamine. I do not believe there are any interactions between this and Xanax (alprazolam). You can take them together and at .125 mg dose, would not expect any interactions or side effects.

Answered 3/16/2019

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Dr. Paul Grin answered

Specializes in Pain Management

Zyrtec and Xanax (alprazolam): 1. No waiting is needed. No drug interactions. It is good idea to take Xanax (alprazolam) 1 hour before bed time. 2. Zyrtec is an antihistamine medication. The average elimination half-life is 8 hours. It takes approximately 6 half lives for a drug to be eliminated from your system. 8*6/24= 2 days. The Zyrtec will stay in your system for about 2 days. Hope it helps.

Answered 2/24/2018

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