A member asked:

Why are women the cause of down syndrome more often than men are?

6 doctors weighed in across 2 answers

Non dysjunction: This term means that one of the earliest divisions of the embryo after conception delivers 3 number 5 chromosomes to a daughter cell and only one to the other daughter cell. The trisomy cell survives to create down's syndrome babies.

Answered 11/14/2015

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The way things are: The male contribution to conception comes from a stem cell system continuously producing new sperm from puberty until ??The healthiest sperm are the most likely to complete the process. (defective ones don't swim as well) Women usually release one egg at a time, that represents accumulated age/toxic exposures/etc.If an extra 21 chromosome is in an egg, it produces a defective but survivable embryo

Answered 11/14/2015

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