I would like the opinion of a doc who knows lyme.does a negative igg and igm exclude 100% lyme?got brain lesions, fever for years, anxiety, ms excluded.

NO, does NOT exclude: One of the reasons there is so much controversy about Lyme is that the tests are imperfect, with both false positives and false negatives. 20-30% of those with Lyme may have a negative Western Blot. With your symptoms I would be very suspicious for Lyme. It is ideal to work with a doctor knowledgeable about Lyme who uses an integrative approach. See http://www.betterhealthguy.com/lyme/testing