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A 44-year-old member asked:

What role does the immune system play with ms?

3 doctor answers6 doctors weighed in
Dr. Virginia Simnad
Neurology 28 years experience
Pivotal role: This is a complex and not fully understood aspect of ms. Certain immune cell population recognize proteins in the insulation coating surround nerve fibers in the central nervous system as "foreign". This results in a cascade of events leading to injury of the insulation material and underlying nerve fiber. Other factors possibly separate from immune attack also play a role in ms.
Dr. Jack Mutnick
Allergy and Immunology 17 years experience
Autoimmune disease: Ms is an autoimmune disease, so the antibodies in your system are working adversely against the neurologic system in your body. Much of the treatment is aimed at down-regulating this aberrant immune reaction.
Dr. Bennett Machanic
Neurology 52 years experience
Very complicated: Latest info suggests an inborn genetic susceptibility with environmental triggering events. The basic pathology causes the immune system to mistake brain and spinal cord myelin as a foreign entity. Data regarding grey matter involvement is starting to explain much of what is occurring. All current meds target lymphocyte trafficking, (t cells), but the b cell research is exciting.

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Last updated Jun 24, 2015
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