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A 52-year-old female asked:

I have primary immune deficiency, ms, pots, ra, raynauds, etc... no response to pneumovax or prevnar (pneumococcal vaccine). anas always neg. sero-negative. please help!

3 doctor answers4 doctors weighed in
Dr. John Chiu
Allergy and Immunology 57 years experience
Consult immunologist: It appears that you need immunoglobulin G replacement. Otherwise your case is quite complex and would need the help of an immunologist and a rheumatologist preferably in an university center.
Dr. Satish Sundar
Pediatrics 34 years experience
Sorry to hear that..: Please consult your immunologist. Seroconversion to vaccines is hard with various forms of immunodeficiency. I wish I could give you a quick answer. BUt non live vaccines would be safe for yo. Both those can be given to you, but one cannot as evident guarantee protective titres.
Dr. Felix Brizuela
Neurology 32 years experience
sounds like you need to be on intravenous immune globulin. I would either consult with immunologist and/or see rheumatologist about this. Sometimes people with immune deficiency can sometimes also have and immune mediated disorder. Going on IVIG may resolve many of your issues.
Oct 23, 2014
Dr. Amrita Dosanjh
Pediatric Pulmonology 36 years experience
Workup and Mgt: There are many PIDs and some are associated with autoimmune disease. Since there is so much variation, the diagnosis can be difficult. If you are prone to infections, the pattern of the infections, type and location will help your physician determine the diagnosis and treatment. If you have lung involvement, an HRCT is helpful. Most PIDs involve B cells and I would advise B cell studies.

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Last updated Dec 3, 2015

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