A member asked:

I have primary immune deficiency, ms, pots, ra, raynauds, etc... no response to pneumovax or prevnar (pneumococcal vaccine). anas always neg. sero-negative. please help!

4 doctors weighed in across 3 answers
Dr. John Chiu answered

Consult immunologist: It appears that you need immunoglobulin G replacement. Otherwise your case is quite complex and would need the help of an immunologist and a rheumatologist preferably in an university center.

Answered 12/3/2015

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Sorry to hear that..: Please consult your immunologist. Seroconversion to vaccines is hard with various forms of immunodeficiency. I wish I could give you a quick answer. BUt non live vaccines would be safe for yo. Both those can be given to you, but one cannot as evident guarantee protective titres.

Answered 3/9/2015

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Dr. Amrita Dosanjh answered

Specializes in Pediatric Allergy and Asthma

Workup and Mgt: There are many PIDs and some are associated with autoimmune disease. Since there is so much variation, the diagnosis can be difficult. If you are prone to infections, the pattern of the infections, type and location will help your physician determine the diagnosis and treatment. If you have lung involvement, an HRCT is helpful. Most PIDs involve B cells and I would advise B cell studies.

Answered 3/9/2015

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