Best working antidepressant medication? any tips?

None is "best": There are no reliable differences in how well different antidepressants work. For this reason, they are mostly prescribed on the basis of side-effects. I.e., more sedating meds when depression interferes with sleep, more activating meds when depression saps daytime energy. Some are more apt to upset stomach, others to lower sex drive. Balancing these factors can be subtle.