Do you know of any hypotheses, ideas or research that's been conducted relating to the link of using isotretinoin and biliary(liver? system disorders?

Here's a good start: See the following drug information link from nih: http://dailymed.Nlm.Nih.Gov/dailymed/archives/fdadruginfo.Cfm?Archiveid=8655. Clinical hepatitis considered to be related to Accutane therapy has been reported, as has pancreatitis. Additionally, mild to moderate elevations of liver enzymes have been observed in approximately 15% of individuals treated during clinical trials.