A 55-year-old male asked:
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Is luvox (fluvoxamine) the only ssri which acts on melatonin?

1 doctor answer
Dr. Pamela Pappas
41 years experience in Psychiatry
Drug interaction: Luvox (fluvoxamine) doesn't directly "act on" melatonin. Instead, it inhibits the enzyme [cyp 1a2] which helps break melatonin down in your body. This increases the amount of melatonin that your body absorbs -- thereby increasing its effects and side effects. And yes, Luvox (fluvoxamine) is the only ssri which acts so potently on cyp 1a2.
Answered on Apr 14, 2016
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Related questions:

A 55-year-old male asked:
Dr. Douglas Bey
56 years experience in Psychiatry
No: Its a ssri that's been around a while. No "healthier" than any of the others.
A 55-year-old male asked:
Dr. Pamela Pappas
41 years experience in Psychiatry
Luvox (fluvoxamine): You're referring to luvox (fluvoxamine)'s ability to inhibit the liver enzyme cyp1a2, which is needed to process both caffeine and melatonin. Both o ... Read More
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A 55-year-old male asked:
Dr. Ronald Krauser
51 years experience in Rheumatology
Does not matter: Timing is not important but this med is usually dosed in the morning.
A 55-year-old male asked:
Dr. Andrew Kaplan
11 years experience in Psychiatry
Yes: Yes. Make your prescriber aware of all you're taking, including OTC substances like melatonin.

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