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A female asked:

How is topical baclofen cream metabolized? does it still work on your cns and metabolized through the kidney? what about topical gabapentin?

1 doctor answer3 doctors weighed in
Dr. Paul Grin
Pain Management 37 years experience
Transdermal- topical: A topical application of a medication to the skin is used solely for its local effect at the site of pain generation. While transdermal medications are also applied directly to the skin, their target site of action can be distant from the site of drug application. The site of activity of a transdermal drug is not achieved locally, but systemically. The drug is pushed into a blood stream.
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Last updated Jun 16, 2019

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