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A member asked:
Is it safe to take vyvanse and benadryl (diphenhydramine)?
13 doctors weighed in across 3 answers
OK Benedryl+Vyvanse: Benedryl is an 'sedating' antihistamine and is safe with Vyvanse (lisdexamfetamine) (add med) benedryl is best dosed @ night.
Answered 8/3/2020
5.9k views
Safe but not advised: Benadryl (diphenhydramine) is too sedating, resulting often in some cognitive suppression. The reason for taking the Vyvanse in the 1st place is to enhance cognition. There are better antihistamines. And, if the purpose of the Benadryl (diphenhydramine) is to help sleep at night, there are better choices.
Answered 5/13/2019
5.9k views
Conflicting: the sedating effect of benedryl may offset the stimulant effect of Vyvanse (lisdexamfetamine). Be careful of driving and using machines until you are sure the benedryl is not sedating.
Answered 2/9/2019
3k views
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