A member asked:

Never taken antidepressants but tested + for tca. i take prescribed vyvanse (lisdexamfetamine) & an otc diphenhydramine sleep aid only. can either have lead to a false +?

A doctor has provided 1 answer
Dr. Jeremy Porter answered

Specializes in Pediatrics

Benadryl (diphenhydramine) : If you do not take any tricyclic antidepressants, and have a positive TCA on a toxicology screen, is likely the diphenhydramine that you're taking, which can sometimes give a false positive for TCA. If the Vyvanse (lisdexamfetamine) hinders your nighttime sleep, consider taking melatonin rather than diphenhydramine for long-term use.

Answered 8/25/2016

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