Is micro vascular disease typically picked up on a nuclear stress test?

Generally, no.: Nuclear stress test is a functional test, which is different from cath or cta. In most cases of microvascular disease, nuclear stress test may be false-negative due to collateral circulation.

It can be: What you are referring to is called subendocardial ischemia. Often times on a nuclear stress test people with subendocardial ischemia will have an elevated TID ( where the stress half of the nuclear image has a dilated left ventricular cavity compared to the rest half of the nuclear image). This is called transient ischemic dilation. Usually a TID of 1.36 or greater is concerning.