Yes, it can, but: It has been reported infrequently. More common is the scenario where a patient was switched from a medication that caused a lot of weight gain to seroquel (quetiapine) and weight loss occurred because of the absence of the weight inducing agent. If your weight loss is sudden and unexpected, please check with your doctor to rule out other physical causes including hyperthyroidism, etc. Best wishes.
Answered 7/5/2020
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Seroquel: Seroquel is associated with Weight gain in up to 45% of people. Weight loss is uncommon at only 0.1% to 1%.
Answered 7/6/2020
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