A 42-year-old member asked:
Please explain what are the differences between glyburide and glimepiride medications?
1 doctor answer • 3 doctors weighed in
A Verified Doctoranswered
33 years experience
Similar mechanisms: Hi. Glyburide & glimepiride (& glipizide & others in the sulfonylurea class, for that matter) all work by the same mechanism to stimulate endogenous insulin release. They differ in duration of action, metabolites, accumulation in kidney disease, etc. They're archaic drugs that I never use anymore. There are much better type 2 drugs out there. Their one benefit - they're cheap.
Created for people with ongoing healthcare needs but benefits everyone.
3.9k viewsReviewed >2 years ago
Similar questions
A 36-year-old member asked:
What difference is there between glyburide and glimepiride medications?
2 doctor answers • 3 doctors weighed in
A Verified Doctoranswered
33 years experience
Same family: Hi. Glyburide is a second generation sulfonylurea and glimepiride is a 3rd generation. They work at the same receptors on the beta cell (the pancreatic cells that make insulin) and stimulate insulin release. Glimepiride is preferable because of less metabolite build up in kidney disease, but they're VERY similar. I never use them. In my opinion, based on good science, we have much better drugs.
Created for people with ongoing healthcare needs but benefits everyone.
3.5k viewsReviewed >2 years ago
Last updated Sep 17, 2016
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