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A member asked:

My girlfriend was prescribed sertraline and amitriptyline. i've heard mixing them isnt a good idea the risks outweigh the benefits. what do you think.

A doctor has provided 1 answer

I have plenty of: Patients on the combination. The main risk is the zoloft (sertraline) driving up the blood level of the elavil, so i always check Elavil levels and use low doses. Serotonin syndrome is very rare in my experience. I've seen two cases in 30 years of practice. Best wishes.

Dr Altman agreed

Answered 5/15/2018

4.3k views

Thank

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