What is the best treatment for vitiligo

Difficult problem: Vitiligo can be a frustrating disease due to it's cosmetic result. Treating vitiligo can be difficult. Usual treatments include topical steroid, intralesional steroid shot and or light therapy. For significant vitiligo you should consult a dermatologist who has experience in this area.

Rule out underlying: Some cases of vitiligo (a minority) are caused by an underlying medical condition. It is important to rule out those conditions, since treating them will often stop the vitiligo. Assuming there is no underlying condition, tacrolimus ointment, corticosteroid creams, and intralesional steroid injections are pretty much the only options at the present time.