Is it safe to take lorazepam 0.5 mg with the pain medicine hydrocodine 10.325 and flexiral 10 mg?

Call doctor: Individually, those drugs produce drowsiness. Combined, they produce incredible drowsiness. You can't be driving, or operating machinery, or doing anything requiring tremendous attention while you're taking any one of those drugs. So you should contact your doctor first, and discuss what the real issue is, before considering taking more than one of them. Taking two narcotics plus a muscle relaxant can cause problems together.