A member asked:

What is malignant hyperthermia?

5 doctors weighed in across 2 answers

MH- temp, HR, etc: Mh is an inherited disease that is typically uncovered after the affected person gets anesthesia for surgery. Symptoms include muscle rigidity, fast, irregular heart rate, rapid rise in body temperature to 104f or higher. Mh can lead to muscle breakdown, kidney failure and death. There may be a family history of mh or unexplained death during anesthesia. Mh differs from hyperthermia (heat stroke).

Answered 2/24/2023

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Anesthetic reaction: Malignant hyperthermia is a serious, possibly life threatening reaction to certain anesthetic agents including succinylcholine and inhaled anesthetic gases. This condition is often inherited, and involves a mutation of a gene in muscles involved in calcium release. When exposed to triggering agents, the muscles undergo excessive metabolism, leading to muscle breakdown and heat, which cause death.

Answered 9/3/2012

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