Possibly.: Both are drying to the skin and can be irritating. So, although there is no absolute contraindication to using them together, you would need to be very cautious. If there is any sign of redness or irritation, I would stop them and consult your dermatologist/doctor who is prescribing the Epiduo. Also, it is probably not necessary to use the witch hazel if you are using the Epiduo.
Answered 11/28/2017
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