Had a mild allergic reaction to diflucan (fluconazole) will the medications still work?

You should: Not taken Diflucan (fluconazole) if you are allergic to it. Do not use any drug from the class of drugs called azole antifungals. Rec.: see a prescribing physician a medicine adjustment.

No answer: "Mild allergic reaction"??????What is that????? Yes, it will still reduce the population of yeasts. MOST, not all, but MOST of the time a person thinks they are "allergic" to a med they are mistaken. Unless you provide details about the "mild" reaction, I will assume that you are not sensitive to fluconazole.