A member asked:

Why sickle cell anemeia / multiple myeloma cause diabetes insipidus ? is it because it may obstruct the blood flow to the kidneys and damage them?

A doctor has provided 1 answer

Basically right: Even sickle cell trait ruins much of the concentrating ability of the kidneys by adulthood. Myeloma is more likely to damage and obstruct the tubules themselves. Both produce a kidney lesion that prevents the urine from becoming concentrated, rather than a pituitary diabetes insipidus.

Answered 11/27/2017

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