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Edmonds, WA
A 31-year-old male asked:

can i experience antidepressant withdrawal when transitioning from a tricyclic to an ssri? if so, what are some of the symptoms?

1 doctor answer3 doctors weighed in
Dr. Donald Jacobson
A Verified Doctor answered
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Yes: Symptoms of gastrointestinal and somatic distress, sleep disturbance, and movement disorders and mania have been temporally linked to withdrawal of tcas. Cholinergic and adrenergic overdrive after tca discontinuation have been suggested as the proposed mechanism for this syndrome. Reported symptoms may be psychosomatic or related to underlying mental illness. www.ncbi.nlm.nih.gov/pubmed/8219442.

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Last updated Apr 8, 2016
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