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A member asked:
What's the difference between ssri antidepressants and tricyclic antidepressants?
5 doctors weighed in across 2 answers
SSRI's vs Tricyclics: The ssri's focus on blocking serotonin reuptake, and the tricyclics are non-selective in their receptor activity. Histamine blockade and others in tca's causes more sedation; there can also be postural hypotension with tca's. Ssri's may be safer in overdose, less likely to cause arrhythmia -- could be important in patients w/heart disease. Ssri's have their own side effect profile though.
Answered 5/7/2016
5.6k views
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