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Coraopolis, PA
A 35-year-old female asked:

5hiaa test came back at 6.5. i followed the food restrictions strictly the day of but not before. i did not stop medications which include dostinex, ibuprofen, xanax, (alprazolam) excedrin. should i retake test?

2 doctor answers3 doctors weighed in
Dr. Alan Feldman
Endocrinology 41 years experience
Yes: In most labs, the normal range for 5hiaa is 2 to 8, so 6.5 would be normal. Excedrin contains caffeine, which should not be ingested during the urine collection. It would therefore be reasonable to repeat the test. One could also get a chromogranin a level, and urine serotonin levels, but these are both less sensitive and specific compared to the 5hiaa level.
Dr. Ed Friedlander
Pathology 44 years experience
Up to your doctor: This is very slightly above the reference range and many normal folks will be here. Whether to repeat will depend on your physician's index of suspicion for carcinoid. I would not be surprised if you have some imaging in your future.

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