Can i use st johns wort instead of antidepressants?

It is best not to.: St. John’s wort, a plant that grows in the wild, has been used for centuries for health purposes. However, consumers need to be aware of serious concerns about its safety and effectiveness. This fact sheet summarizes scientific research on st. John’s wort for depression and suggests st. John’s wort may help some types of depression, but may effect serrotonin a brain chemical targeted by antidep.

St John's wort: "A 2009 systematic review of 29 international studies suggested that St. John’s wort may be better than a placebo (an inactive substance that appears identical to the study substance) and as effective as standard prescription antidepressants for major depression of mild to moderate severity." REF: https://nccih.nih.gov/health/stjohnswort/sjw-and-depression.htm. However, many studies are from