Is beta blocker or calcium channel blocker safer in 1st trimester pregnancy?

Class C: Class c means no studies have been performed and safety is uncertain. Class b is better. All calcium blockers and all beta blockers except Acebutolol are class c. Acebutolol (a beta blocker) is class b. Class b means that animal studies have shown safety but no human studies have been done. None of the drugs are class a (safest) and risk should always be balanced against need.

Calcium blocker: Calcium channel blockers are often used for the management of hypertension in pregnancy. Beta blockers are classified as pregnancy category c, meaning that they have not been systematically studied. Although both classes of medications are used in pregnancy, calcium channel blockers are likely to be safer.