A member asked:

I was taking vicodin 5-550 for a torn meniscus. now i have 5-325 and it is not working. why?

2 doctors weighed in across 2 answers

Not sure.: Seems like little difference between the two doses, but it is possible that you might need to increase the dose a bit. The other possibility is that you have irritated your injury a little bit more therefore it requires a bit more med.

Answered 1/24/2014

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Dr. Paul Grin answered

Specializes in Pain Management

Add adjuvant agent: In some patients, the use of an opioid drug alone may cause intolerable side effects or provide inadequate pain relief. To avoid this problem, the use of adjuvant (co-analgesic) nonopioid agents along with an opioid is encouraged to reduce the amount of the single opioid needed. Examples are oral corticosteroids, tricyclic antidepressants, anticonvulsants, and skeletal muscle relaxants.

Answered 1/24/2014

4.5k views

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