Why does diabetes result in heart, kidney failures and blindness?

Diabetic angiopathy: Retinopathy (r) and nephnropathy (n) are seen in diabetic patients. They are an example of microangiopathy (m) in diabetes, due endothelial dysfunction (e). M is affected more by BP as you can see in the slide. Heart disease is also affected by e and it is known as macroangiopathy (ma). Control of bp, glucose and drugs that treat angiopathies, such as ace-i agents are needed to prevent m and ma.

Major risk factor. : Diabetes has become exceedingly common, and so have its complications, which include coronary heart disease (chd), stroke, peripheral arterial disease, nephropathy, retinopathy, and possibly neuropathy and cardiomyopathy. Exact mechanisms are not clearly understood but has to do with long term effects of consistently high blood sugar levels leading to various tissue damage in certain organs.