Enlarged spleen caused by gallbladder disease, what to do?

Probably not GB: Gallbladder disease, most frequently cholecystitis, or inflammation of the gallbladder, does not cause enlarged spleen. Under very unusual circumstances, bacterial infection could cause some response or abscess in the spleen. More often, enlarged spleen or splenomegaly is a reflection of liver disorder, in which the gallbladder may also be affected. Check with your doctor.