My 15 month old son was advised to take prednisolone syp 5 ml tid, since he slept i couldn't give the medicine in 8 hour interval so gave it 6 hours early. is it safe?

Ok once in a while: No problem. These things happen with their sleep, and other unpredictable happenings! do the best you can to follow the instructions as often as you can. You sound like a conscientious mom! hope he's feeling and doing better soon!

PREDNISONE DOSE: Prednisone/prednisolone can be given 12 hourly dose or once a day. Don't worry. Total daily dose is important.

Yes: Timing does not matter with this, as long as the total dose is given each day. You can even give the entire 3 doses as one. Make sure he has food in his stomach when you give it.