Will decreasing mirtazipine result in side effects recurring? i.e..at 15mg sleep and eating too much was an issue..im currently on 45mg

Unlikely: Side effects are usually more pronounced at the beginning of the treatment and lowering the dose should not evoke them.

Mirtazapine: Contrary to conventional knowledge, Mirtazapine will be more sedating at lower doses. If you reduce the dose from 45 mg to 15 mg, it is possible that you will suffer more tiredness and sedation. It is possible that the same will happen with appetite. Mirtazapine has the quality of increasing the levels of triglycerides, reaching in some cases very high levels (up to the thousands).

Mirtazapine (MTZ): Mtz (adrenergic receptor antagonist w/ indirect serotonin activation) is generally well-tolerated. It has a quick onset of action. Se’s = drowsiness, constipation, wt. Gain, dry mouth ; rarely, suicidal ideation. Sudden stopping can cause anxiety, dizziness, irritability, diarrhea, decreased appetite ; flu-like symptoms. Slow dose reduction reduces se's. Speak w/ provider before changing dose.