can you please suggest treatment for progressive supranuclear palsy ( psp)?

Question

I was diagnosed with progressive supranuclear palsy 5 years ago. Are there any good clinical trials available for psp?

Answer 1

Multidisciplinary: While there is no single effective medication to stop the progression of psp; some short term modest benefit has been shown with bromocriptine for the rigidity, Botox for dystonia and sialorrhea, methylcellulose for dry eyes, and cognitive stimulation/physical exercise for cognitive function and gait and balance training.

Answer 2

Largely ineffective: Parkinson's meds (eg levodopa) and therapy (physical/ occupational/ speech/ swallow) might help a bit, but their benefits tend to be very limited in psp.

Answer 3

Good Rx available!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile.

Answer 4

The right doctor: I believe it is important to be seen by a movement disorders neurologist for this neurodegenerative disease. This is a very difficult disease to treat. A patient may need very high doses of levodopa. Oftentimes issues such as feeding tubes are at the fore. A specialist will have more experience dealing with this rare disease and may have other options (i.e. Clinical trials) available.

Answer 5

Ceftriaxone, others: Duplicate question, same answer: Azithromycin by itself is not used for gonorrhea treatment unless other first-line treatments cannot be given, such as drug allergy. When used for gonorrhea, a 2 gram dose of AZM is needed (vs. 1 gram for chlamydia). Has persistent gonorrhea been professionally diagnosed? If so, I would recommend ceftriaxone plus doxycycline. Discuss with your doctor or clinic

Answer 6

Ceftriaxone, others: Azithromycin alone is not recommended for gonorrhea treatment unless there is a reason that other first-line treatments cannot be given, such as drug allergy. When used for gonorrhea, a 2 gram dose of AZM is needed (compared with 1.0 g for chlamydia). Has persistent gonorrhea been professionally diagnosed? If so, I would recommend ceftriaxone plus doxycycline. Discuss with your doctor or clinic

Answer 7

YES: The previous name for psp was steele-richardson-olszewski syndrome.

Answer 8

Named after Pioneers: It's also known as steele-richardson-olszewski syndrome, after the three physicians who pioneered it's characterization. Look at this link, which will tell you far more detail about psp than i can possibly write here (space limited): ******************************http://en.M.Wikipedia.Org/wiki/progressive_supranuclear_palsy.

Answer 9

Falls: Usually starts with falls swallowing difficulties are also seen.

Answer 10

Bad illness: Lose ability to move eyes properly, lose ability to balance and walk, have twisting dystonic posture of spine. Not curable or easily treated, and hope you or family members do not have.

Answer 11

Not good: Not very much except for supportive care. Doesn't respond well to drugs used for other types of parkinson's.

Answer 12

Good Rx Available!!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile.

Answer 13

The right doctor: I believe it is important to be seen by a movement disorders neurologist for this neurodegenerative disease. This is a very difficult disease to treat. A patient may need very high doses of levodopa. Oftentimes issues such as feeding tubes are at the fore. A specialist will have more experience dealing with this rare disease and may have other options (i.e. Clinical trials) available.

Answer 14

Tamoxifen: Tamoxifen has been the standard drug that blocks estrogen receptors in patients whose tumors are considered ER+ A new type of anti-estrogen drug appears to work better than the estrogen-blocking drug tamoxifen . Exemestane (Aromasin), belongs to a class of drugs called aromatase inhibitors. But, for exemestane to work in premenopausal women, the drug can only be given when ovarian function is being suppressed.The Aromatase inhibitors, work by preventing other hormones from changing into estrogen, which fuels certain cancer growths

Answer 15

2 means: Hi. Estrogen receptor antagonists, like tamoxifen or raloxifine, or aromatase inhibitors, which prevent the endogenous synthesis of estrogen, are the two major categories. The main estrogen-driven tumors are ER + beast CA and endometrial CA. Good luck, and beat the CA!

Answer 16

PSP: Progressive supranuclear palsy: the disorder's long name indicates that the disease begins slowly and continues to get worse (progressive), and causes weakness (palsy) by damaging certain parts of the brain above pea-sized structures called nuclei that control eye movements (supranuclear). It is central; demyelinating conditions occur in the peripheral nervous system.

Answer 17

No, tau protein: No, tau protein deposits & neurofibrillary tangles in neurons cause the death of these cells. Because they are in some similar areas as parkinson's disease, psp can appear similar clinically, but there are clear differences. Treatment approaches are roughly the same with different areas needing most attention. Primarily balance/falls/injury, did inhibiting dementia & dysphagia/aspiration.

can you please suggest treatment for progressive supranuclear palsy ( psp)?

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