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A 48-year-old member asked:

i was wondering what are 4 neurotransmitters affected by tricyclics antidepressants?

2 doctor answers3 doctors weighed in
Dr. Alan Koenigsberg
Psychiatry 42 years experience
See below: All of the commonly used antidepressants work primarily on two neurotransmitters, norepinephrine and serotonin. Dopamine is affected by serotonin levels, and acetylcholine may also be affected. Changing the levels of serotonin and norepinephrine are currently believe to be the main effect which alleviates depressive symptoms. There are many other neurotransmitters that are involved...Stay tuned.
Dr. James Wells
Psychiatry 44 years experience
Primarily 2 affected: Tricyclic antidepressants like amitriptyline, imipramine, desipramine, nortriptyline, clomipramine, doxepine, protriptyline, trimipramine, among others, primarily act to increase serotonin ; norepinephrine but with some also affecting to a lesser degree Dopamine ; histamine. Mono-amine-oxidase-inhibitor (maoi), Parnate (tranylcypromine) (tranylcipramine), affects serotonin, epinephrine, norepinephrine, ; dopamine.

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Similar questions

A 35-year-old member asked:

Is it ok to take antidepressants during pregnancy?

2 doctor answers9 doctors weighed in
Dr. R. Wayne Inzer
Specializes in Obstetrics and Gynecology
Varies: Most are cat c meaning concerns exist for animal studies and not proven safe in preg humans. There are times when a pt. And her baby are safer taking an antidepressant, esp if suicide is a risk. You and your physician can decide together what is best for you.
A 29-year-old member asked:

Is it safe to take anti-depressants while pregnant?

1 doctor answer1 doctor weighed in
Dr. Aileen Caceres
Specializes in Obstetrics and Gynecology
Yes: Antidepressants may be used in pregnancy for patients who need to be treated. The most common medications are selective serotonin re-uptake inhibitors (such as fluoxetine, paroxetine or sertraline). Because these agents have few side effects, they are a good therapeutic choice for women. Always check with your obstetrician before continuing or starting any new medications during pregnancy.
A 35-year-old member asked:

Is it safe to take antidepressants while pregnant?

3 doctor answers8 doctors weighed in
Dr. Padmavati Garvey
A Verified Doctoranswered
A US doctor answeredLearn more
No: All the current antidepressants have been associated with increased jitteriness in the baby, increased chances of baby going to intensive care unit because of mild breathing issues. In addition, there is a rare but serious problem called primary pulmonary hypertension that can develop. You should talk to your OB and therapist to see if you can handle stopping the antidepressants.
A 26-year-old member asked:

Is it safe to stop using antidepressants while pregnant?

2 doctor answers4 doctors weighed in
Dr. Padmavati Garvey
A Verified Doctoranswered
A US doctor answeredLearn more
Yes: As long as your depression will not get worse to cause harm to you. Ideally it is better to be off antidepressants while pregnant so long as your health and safety are ok.
A 38-year-old member asked:

Are antidepressants needed to get over the baby blues?

3 doctor answers5 doctors weighed in
Dr. Sheila Goodman
Specializes in Obstetrics and Gynecology
Not normally: Baby blues is normally a brief period of uncontrolled crying that occurs in the first couple of weeks after delivery. It is mainly related to the hormone shifts that happen after delivery and sleep deprivation. If a new mother is finding that her moods are bad enough to affect her ability to take care of herself or her children, that is postpartum depression, not baby blues, and needs treatment.

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Last updated Jun 30, 2014
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