U.S. doctors online nowAsk doctors free
A 48-year-old member asked:

I was wondering what are 4 neurotransmitters affected by tricyclics antidepressants?

2 doctor answers3 doctors weighed in
Dr. Alan Koenigsberg
Psychiatry 43 years experience
See below: All of the commonly used antidepressants work primarily on two neurotransmitters, norepinephrine and serotonin. Dopamine is affected by serotonin levels, and acetylcholine may also be affected. Changing the levels of serotonin and norepinephrine are currently believe to be the main effect which alleviates depressive symptoms. There are many other neurotransmitters that are involved...Stay tuned.
Dr. James Wells
Psychiatry 45 years experience
Primarily 2 affected: Tricyclic antidepressants like amitriptyline, imipramine, desipramine, nortriptyline, clomipramine, doxepine, protriptyline, trimipramine, among others, primarily act to increase serotonin ; norepinephrine but with some also affecting to a lesser degree Dopamine ; histamine. Mono-amine-oxidase-inhibitor (maoi), Parnate (tranylcypromine) (tranylcipramine), affects serotonin, epinephrine, norepinephrine, ; dopamine.

Related questions

A 41-year-old member asked:
Could these antidepressants be affecting my erections?
2 doctor answers5 doctors weighed in
A 30-year-old member asked:
Which neurotransmitters are possibly affected by huntington's disease?
2 doctor answers5 doctors weighed in
Last updated Jun 30, 2014


Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.