A member asked:

I was wondering what are 4 neurotransmitters affected by tricyclics antidepressants?

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Dr. Alan Koenigsberg answered

Specializes in Psychiatry

See below: All of the commonly used antidepressants work primarily on two neurotransmitters, norepinephrine and serotonin. Dopamine is affected by serotonin levels, and acetylcholine may also be affected. Changing the levels of serotonin and norepinephrine are currently believe to be the main effect which alleviates depressive symptoms. There are many other neurotransmitters that are involved...Stay tuned.

Answered 6/25/2014

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Primarily 2 affected: Tricyclic antidepressants like amitriptyline, imipramine, desipramine, nortriptyline, clomipramine, doxepine, protriptyline, trimipramine, among others, primarily act to increase serotonin ; norepinephrine but with some also affecting to a lesser degree Dopamine ; histamine. Mono-amine-oxidase-inhibitor (maoi), Parnate (tranylcypromine) (tranylcipramine), affects serotonin, epinephrine, norepinephrine, ; dopamine.

Answered 6/30/2014

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