A member asked:

Ive read that anticholinergic drugs block acetylcholine, causing mental deterioration.is this a concern if you're not eldery? taking amitriptyline 25

9 doctors weighed in across 2 answers

Proper doses: Taking proper doses of anticholinergic medications should not affect cognitive function in younger patients. Some elderly patients and patients on certain other type medications can be affected.

Answered 2/1/2015

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Minimal concern: Correct. Amitriptylline has anticholinergic properties. It's been around for many years and is a very useful drug for a variety of medical problems and also relatively inexpensive. 25 mg is a low and well tolerated dose. Cognitive changes in the elderly a concern given age-related mental decline, other diseases, and the fact that they are often on other meds with anticholinergic effects- additive.

Answered 1/21/2017

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