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A member asked:
For the pathologists, when testing for antibodies, if there is a perinuclear staining of some cells of a human pituitary, what could this indicate?
4 doctors weighed in across 2 answers
Confirmation: Crooke's hyaline change is altered perinuclear cytokeratin (photo). Keratins (cam 5.2, others) in hgh-omas and prolactinomas are usually perinuclear. Nesp55 is new and often perinuclear in adenomas. At present, i don't know of any treatment decisions that will be based solely on either of these immunostaining staining patterns.
Answered 12/26/2013
4.6k views
Maybe adenoma: Perinuclear staining means that the cells stained around the nucleus, but it doesn't tell what exactly stained. Pituitary adenomas, which are benign tumors, can show perinuclear staining with an antibody to cytokeratin. Looking at staining patterns is one way to tell the difference between types of pituitary tumors. We need more information from your pathology report to answer this.
Answered 3/17/2014
4.6k views
Related Questions
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I have no hunger, no fever response, cold/heat intolerance, dysesthesias. Thyroid is normal..No thyroid antibody. Hapothalamus/pituitary issue?
A doctor has provided 1 answer
A member asked:
Firstabale sorry English my first language . I wanna ask about slight high prolactin . It was 20 Ng/ml . Symptoms I'm experience Low libido , low T , no motivation , hot flashes ,blurred vision . Also I have high thyroid antibodies ? Pituitary MRI to?
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A member asked:
What's the difference on Antibodies/Antigens on the exterior of the cell vs the interior while testing and worried about the sensitivity/accuracy?
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