A member asked:

What is the basic cause of klinefelter syndrome?

3 doctors weighed in across 2 answers

Extra X chromosome: The phenotypic male, with a y chromosome, has more than on x chromosome, associated with poor testicular development, infertility and obesity.

Answered 3/21/2017

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Extra chromosome: The egg is supposed to have only one of the chromosome pairs as they await fertilization. If the sex chromosome did not separate properly when the egg formed,it remains behind and the sex "pair" of the embryo becomes a sex triplet. The XXY joins the other 22 pairs of chromosomes to build the fetus. The extra is not enough to cause fetal loss, but the resulting baby has Klinefelter and its problems

Answered 9/15/2015

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