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A 36-year-old member asked:

Can there be such a thing as a non-ssri anti-depressant?

1 doctor answer3 doctors weighed in
Dr. Alan Koenigsberg
Psychiatry 42 years experience
Yes: Bupropion, or wellbutrin, (bupropion) is primarily a norepiphrine antidepressant. It does not cause side effects typically associated with ssri antidepressants. The try cyclic antidepressants, which were commonly prescribed in the seventies and eighties, affect multiple neurotransmitters in addition to serotonin. The newer antidepressants, the snri's, affect both serotonin and norepinephrine.

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Last updated Mar 14, 2015

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