Is it ok to do a colon cleanse with epsom salt while on prozac (fluoxetine)?

Not advised: I would not advise doing a colon cleanse with epsom salts under any circumstances. Your colon has natural ways of cleansing itself, especially with good diet (lots of fiber from veggies, no processed foods, low sugar, grass-fed meats if meat is eaten, etc) and plenty of drinking water. Some people also use periodic fasting (meaning 1 day or so) with green juices, etc.