A member asked:

What is (are) the mechanism(s) by which benzodiazepines reduce norepinephrine release?

6 doctors weighed in across 2 answers

Here you go: www.socialanxietysupport.com/forum/f30/benzodiazepines... Benzodiazepines and their effect on ... By a reduction of norepinephrine activity in a ... Direct impact on Dopamine release. However, the drugs do interact .. It is all much more complicated then we are told in medical school or residency. In fact, it appears that the entire story has not yet been written as far as benzo's are concerned.

Answered 6/25/2014

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Dr. Pamela Pappas answered

Specializes in Psychiatry

Benzodiazepines: Benzodiazepines do not directly reduce norepinephrine release, but they do enhance the inhibitory gaba-a receptor function in the brain so that nerve cells downstream will be less active -- including norepinephrine-firing ones. The end effect is sedation, emotional calming, decreased muscle tone and coordination, decreased memory function, and a host of other changes.

Answered 12/13/2013

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