Able to stay up all night and the day after for certain reasons. do sedatives wear off eventually without sleeping?

Yes, they can. : It is possible not to feel sleepy or fall asleep with sedative medications. Sometimes sleeplessness is so profound and doesn't respond to those meds. Usually it is due to a hyperaroused state from stress and anxiety. Depression, medical conditions, medicines, caffeine, nicotine, alcohol, learned behavior, eating late, poor sleep habits and disrupted sleep-wake cycles can also cause insomnia.