Severe vomiting: Like trimethoprim-sulfamethoxazole , Metronidazole and alcohol can cause a Disulfiram -like reaction similar the drug, Antabuse (disulfiram) - resulting in violent vomiting. Doxycycline in itself, can cause severe nausea and vomiting. As a result, you will not likely keep you medication down - which ultimately restricts the effectiveness of the vomited antibiotic.
Answered 12/31/2017
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