Pl explain er pr cerbb2 all shows negative , besides not responding to oral treatment, what other significance of this test for breast cancer?

More complex Rx: Er, pr, erbb2 negative is also known as triple negative, estrogen receptor, Progesterone receptor and epidermal growth factor receptor (also known as her2) negative breast cancer (bc) and represents 20-25% of all bc. In general, these bc are more difficult to treat and require more aggressive treatment including platinum based chemo. The most important prognostic feature of any bc is stage.