A member asked:

I take 0.5mg klonopin and 50mg zoloft (sertraline) daily. if i don't take either today, would it be okay to have a few drinks with friends tonight?

6 doctors weighed in across 2 answers
Dr. Pamela Pappas answered

Specializes in Psychiatry

No: You will still have both Klonopin and zoloft (sertraline) in your system, and drinking alcohol is not advised.

Answered 6/27/2016

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No: Zoloft (sertraline) is a zero tolerance alcohol drug. Merely one or two drinks of alcohol on zoloft (sertraline) is enough to stop it working for up to 72 hours. Mixing alcohol with Klonopin is never a good idea because you could find yourself, depending upon your tolerance, drinking yourself under the table without even intending it. Then there are issues pertaining to drinking and driving. Klonopin is an extremely long acting drug that will remain in your system whether you have stopped taking it or not. It will therefore have an additive effect with the alcohol. I would highly recommend you not do this.Always play it on the safe side. You can also ask for a nonalcoholic beverage.

Answered 7/17/2018

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