In general, about how long after i start metoprolol tart before the ses decrease? i've had insomnia, fatigue after workout, slight nausea/depression

Give it several week: Give it several weeks before the symptoms die down. Blood levels of the drug can vary greatly from individual to individual due to differences in how individuals liver processes the medication. In the event that the depression continues, i would recommend you talk to your family doctor about switching to a different medication. Never stop this medication suddenly you can experience rebound hypertension.